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Our research specialises in studying the regulation of neural form and function at the molecular level. Much of our work has focused on studying the roles of transcription factors in the development and patterning of nervous systems from basic neurogenesis through to area specialisation and axonal navigation. More recent work has moved into the domain of regulatory genomics where primary miRNA, mRNA, protein expression data is integrated with a host of genomic meta-data and prior biological knowledge to build an integrated understanding of the underlying biological processes. At a higher level we are applying this systems level molecular view to understanding the regulatory processes controlling synaptic plasticity in neurological disease models and paradigms of learning, memory and cognition.
Post-Doctoral Research Staff
- Matthew Hindle, Post-Doctoral Research Fellow. Non transcriptional oscillator circadian rythmn. [with Prof. Andrew Millar, Sythsys, University of Edinburgh
- Owen Dando, Post-Doctoral Research Fellow, Centre for Brain Development and Repair. Informatics of 'Omics datasets. [with Prof. Peter Kind, CIP, University of Edinburgh
- Katie Emelianova (2012-). Patterns of Molecular Evolution in Begonia [with Catherine Kidner, RBGE].
- Xin He (2012-). Construction of frameworks for meta-genomic analysis of neurological diseases and their applications.
- Maciej Pajak (2013-). Conserved genetic control motifs in synaptic plasticity.
- PhD. studentship. Rule-Based Modelling for Neurological Disease.
- Giuseppe Gallone (2012). Computational Approaches to Discovering Differentiation Genes in the Peripheral Nervous System of Drosophila melanogaster [with Andrew Jarman].
- Catherine Carr (2009). Microarray investigation of the role of Pax6 at the PSPB using a novel tauGFP-Pax6 reporter mouse.
- Jennifer Pinson (2005). The role of Pax6 isoforms in embryonic development.
- David Tyas (2005). Generation of a Pax6 reporter mouse.
- Celestial Yap (2005). The role of cofilin in glioblastoma cell behaviour.
- Owen Dando (2013). Integrating gene regulation and expression data to infer genomic target sequences for the transcription factor Gli3 in the developing mammalian forebrain.
- Maciej Pajak (2013). Classifying temporal RNA expression profiles and dynamic protein interaction network motifs during peripheral nervous system development in the fruitfly, Drosophila melanogaster
- Moo Sin Yeong (2012). Evolution of the cognitive proteome.
- Sthita Mohapatra (2011). Developing a web application for cross taxonomic protein-protein interaction prediction.
- Eleni Flerianou (2010). Implementing a Taverna workflow architecture for regulatory genomics. Researching antibiotic: buy azithromycin online
- Elizabeth Watson (2009). Assessing regulome complexity during Drosophila peripheral nervous system development.
- Hugh Townshend (2007). Computer construction of a gene regulatory network for neurogenesis - the use of existing literature to create a model for Drosophila neurogenesis.
- Benjamin Fenby (2000). Towards a functional assay for Pax6.
- Meera Nair (1999)